This work explores the research on the development of teaching content resources based on virtual reality (VR) technology, integrating 5G networks, cloud storage and cloud rendering, and studies the storage and retrieval technology of multi-modal teaching resources, to construct the multi-modal teaching resource and publishing platform, and carry out immersive teaching activities. This article studies intelligent recommendation algorithms based on knowledge graph technology, designs a curriculum-oriented knowledge map programme, helps to achieve personalized learning for students and differentiated teaching for lecturers, and explores teaching mode reformation. Through immersive teaching practice activities, a questionnaire survey shows that the multi-modal teaching mode based on 5G+VR is more popular among students than the current traditional teaching mode.