Chemical experiment is one of the most indispensable teaching forms to the implementation of comprehensive chemistry education and the key procedure to the cultivation of innovative talents. In order to put the ‘Basic Catalogue’ newly promulgated by the Ministry of Education into practice, a comparative investigation was made between the selected experiments in the new edition of the compulsory chemistry course for senior high school and the chemical experiment activities stipulated in the ‘Basic Catalogue’, the differences were found from above investigation. It was suggested that the four versions of textbooks should learn from each other in teaching. Priority should be given to ensuring that students" basic experiments stipulated in the catalog was completely conducted, and conditions should be created to develop some in-class demonstrations into experiments, so that students can experience the real process of scientific inquiry through chemical experiments, understand the scientific spirit while acquiring chemical knowledge, cultivate scientific thinking and core literacy of chemistry, and develop ideas for solving problems in chemical science, and develop the ability to solve problems in chemical science, So that students can finally make to pass the test of life, to pass the test of science and technology innovation competition between countries, to pass the“Neck” test and to pass the test of independent innovation.