Through data research, students'' problems were clarified. Taking the 2022 Beijing College Entrance Examination Chemistry as an example, the key problems in organic chemistry teaching in senior high schools were studied and corresponding strategies were proposed. Through research, the difficulties of students in learning organic chemistry were identified. Through teaching practice, the teaching strategies to solve the problems of organic functional group transformation, intermediates, quantitative calculation, etc. were summarized. According to the pre and post test data, it is clear that the introduction of advanced thinking model of "electronegativity and covalent bond" in organic chemistry teaching and the breaking of barriers in inorganic and organic chemistry teaching will help students to achieve their core literacy, break through difficulties and improve their problem-solving ability.