Chemistry experiment teaching is an important part of chemistry teaching. Under the background of establishing morality and cultivating people as the fundamental task of education and teaching, experimental teaching reform is very necessary and urgent. The experimental teaching guided by the cultivation of students' chemical core literacy can be deeply reformed from the aspects of teachers' experimental teaching concept innovation, the enhancement of chemical experiment education function, and the refinement of experimental teaching evaluation, so as to improve teachers' teaching ability, give full play to the chemical core literacy cultivation function of chemical experiment, and achieve the educational purpose of Building Morality and cultivating people.